Denver Sports Betting

College Football Week 1 Betting Picks and Predictions

Jalen Hurts Oklahoma

Week one of the college football season is ready to kick off this weekend, and there are some terrific betting opportunities. There are certainly plenty of great games to bet on, but we are going to focus on the three biggest games of the weekend. There is just one top-25 matchup in week one, but there are a handful of other games featuring big schools. Let’s take a quick look at the three biggest games this weekend with a betting pick for each game. 


Auburn Tigers -3.5 vs. Oregon Ducks: Oregon and Auburn are set to matchup at AT&T Stadium in Arlington, Texas in what should be the best game of the weekend. Both of these teams enter the season with title aspirations, but the loser of this game might be eliminated after just one week. Auburn is the 11th ranked team in the country, while Oregon checks in at number 16. The Tigers are planning on starting true freshman Bo Nix at quarterback in this game, and Auburn can’t afford for him to have any growing pains. Oregon is set at quarterback with Justin Herbert back under center, and the Ducks offense should be explosive this season. This should be a terrific game but look for the Auburn defense to be the deciding factor. Bet the Auburn Tigers -3.5 over the Oregon Ducks. 


Oklahoma Sooners -23.5 vs. Houston Cougars: The Oklahoma Sooners will host the Houston Cougars in a week one showdown that should feature a ton of points. Both of these offenses want to throw the ball and play fast, but the defensive units for each team might decide this one. Oklahoma will have Jalen Hurts under center to begin the game, and Hurts should flourish under head coach Lincoln Riley. The Sooners have had two straight Heisman Trophy winning quarterbacks, and they still have a ton of weapons on the outside. Dana Holgorsen is now leading the Houston Cougars program, and he will bring a Big-12 type offense to this team as well. Oklahoma just has way too much talent, and they will win this one with ease. Bet the Oklahoma Sooners -23.5 over the Houston Cougars. 


Louisville Cardinals +20.5 vs. Notre Dame Fighting Irish: The Louisville Cardinals will host the Notre Dame Fighting Irish on Monday night to wrap up week one. Notre Dame is a huge favorite in this game, despite losing a ton of talent to the NFL a season ago. Scott Satterfield will be the new man in charge at Louisville after an extremely impressive run at Appalachian State. The Fighting Irish will be trying to make it to the College Football Playoffs for the second straight season, but they just have too many question marks on their roster. Louisville is expected to be much better this season, and they are going to keep this game close throughout. Take the +20.5 points and bet the Louisville Cardinals in this matchup against the Notre Dame Fighting Irish.

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